HOW TRODELVY IS THOUGHT TO WORK
What TRODELVY is made of
TRODELVY is a type of drug called an antibody-drug conjugate, or ADC for short. ADCs contain 3 parts: an antibody, a linker, and an anti-cancer drug.
Looks for a specific protein, in this case Trop-2, which can be found in high levels on cancer cells.
B. Anti-cancer drug
Kills cancer cells once they’re found.
Connects the anti-cancer drug to the antibody.
How TRODELVY is thought to attack TNBC tumors
Scientists discovered that patients with TNBC have tumor cells that contain a higher than normal level of Trop-2 protein. TRODELVY binds to cancer cells with Trop-2.
The antibody in TRODELVY finds and sticks to the Trop-2 protein on cancer cells.
Once attached, TRODELVY delivers anti-cancer drug directly into the TNBC cells.
TRODELVY kills the TNBC cells from within.
This is how TRODELVY was shown to work in laboratory studies. The clinical benefit of these observations is unknown.