TRODELVY® (sacituzumab govitecan-hziy) is a prescription medicine used to treat adults with hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer that has spread to other parts of the body (metastatic) or cannot be removed by surgery, and who previously received endocrine therapy and at least two additional treatments for metastatic disease. It is not known if TRODELVY is safe and effective in people with moderate or severe liver problems or in children.
Breast cancer is classified by whether or not the cancer cells have certain proteins called receptors. Cancer cells may have receptors for 2 types of hormones (estrogen or progesterone) or another receptor called human epidermal growth factor receptor 2 (HER2).
If estrogen or progesterone hormone receptors are detected in at least 1 out of every 100 cancer cells, the breast cancer is hormone receptor-positive (HR+).
Hormone therapy (also called endocrine therapy) works by interfering with the activity of estrogen and/or progesterone hormones, which cancer cells can use to grow. This is why hormone therapy is a common initial treatment for HR+ breast cancer.
If tests detect low or no HER2 receptors, the breast cancer is considered HER2-negative (HER2-).
TRODELVY was designed for certain patients with previously-treated HER2- breast cancer.
Eventually, hormone therapy can stop working, so your healthcare provider may prescribe systemic treatments that more widely affect your cancer cells.
After many treatments, you may feel like you are running out of options. Your HR+ status may have determined your earlier treatments, but now you can focus on treatments designed specifically for people with HER2- status.
Unlike some other treatments, TRODELVY does not need cancer cells to have estrogen receptors, progesterone receptors, or HER2 in order to work, which is why it is an option for people with HR+/HER2- metastatic breast cancer. TRODELVY is designed to seek out a different protein that may be present on breast cancer cells.
Here are some additional resources that may be helpful to patients, families, and care partners dealing with breast cancer. The following resources are not controlled or owned by Gilead, and Gilead is not responsible for their content.
Breastcancer.org: A complete resource for patients with breast cancer.
Living Beyond Breast Cancer®: Information, community, and support for people whose lives have been impacted by breast cancer.
METAvivor: Dedicated to increasing awareness of advanced breast cancer and equity in research and patient support.
Share Cancer Support: A supportive community of women affected by breast or ovarian cancer.
Sharsheret®: A Jewish breast cancer organization that helps women and their families face breast cancer.
Sisters Network® Inc: Committed to increasing local and national attention to the devastating impact that breast cancer has in the African American community.