Side Effects

WHAT YOU MAY EXPECT

It’s important to understand what side effects may be expected with TRODELVY, including serious side effects. Contact your doctor immediately if you have any side effects. Some side effects may require medical attention and, for some side effects, your doctor may have tips to help you manage or cope with them.

Some side effects of TRODELVY are similar to those you may have had while taking chemotherapy for mTNBC, and the severity is different for everyone. TRODELVY is likely to cause hair loss, even for patients who have not lost hair before. This may happen soon after starting treatment.

The most common side effects seen in ≥25% of patients were:

TRODELVY® (sacituzumab govitecan-hziy) Side effects icon: Decreased white blood cell count

Decreased white blood cell count (neutropenia)

TRODELVY® (sacituzumab govitecan-hziy) Side effects icon: Nausea

Nausea

 
TRODELVY® (sacituzumab govitecan-hziy) Side effects icon: Diarrhea

Diarrhea

TRODELVY® (sacituzumab govitecan-hziy) Side effects icon: feeling tired

Feeling tired

TRODELVY® (sacituzumab govitecan-hziy) Side effects icon: Hair Loss

Hair loss

TRODELVY® (sacituzumab govitecan-hziy) Side effects icon: Diarrhea

Decreased red blood cell count (anemia)

TRODELVY® (sacituzumab govitecan-hziy) Side effects icon: Vomiting

Vomiting

TRODELVY® (sacituzumab govitecan-hziy) Side effects icon: Decreased red blood cell count

Constipation

 
TRODELVY® (sacituzumab govitecan-hziy) Side effects icon: feeling tired

Decreased appetite

TRODELVY® (sacituzumab govitecan-hziy) Side effects icon: feeling tired

Rash

 
TRODELVY® (sacituzumab govitecan-hziy) Side effects icon: Hair Loss

Stomach-area (abdominal) pain or discomfort

TRODELVY also caused serious side effects, including neutropenia, severe diarrhea, serious infusion-related reactions and allergic reactions that can be life-threatening, and nausea and vomiting in the phase 3 trial.

  • Serious adverse reactions occurred in 27% of patients receiving TRODELVY. Serious adverse reactions in >1% of patients receiving TRODELVY included neutropenia (7%), diarrhea (4%), and pneumonia (3%)
  • 5% of patients stopped treatment due to side effects
  • Side effects leading to a treatment interruption of TRODELVY occurred in 63% of patients
  • Doses were reduced for 22% of patients to help manage side effects

Be sure to tell your doctor about any side effects you have while on TRODELVY. They may be able to help by:

  • Recommending medications that support your treatment
    • Granulocyte colony-stimulating factor (G-CSF) was used in 44% of patients who received TRODELVY
  • Reducing/interrupting your dose
  • Discontinuing your treatment with TRODELVY

These are not all of the possible side effects of TRODELVY. Tell your doctor about any side effects that bother you or do not go away. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.