TRODELVY is a type of treatment called an antibody-drug conjugate (ADC) that is designed to work differently than traditional chemotherapy. It is designed to deliver powerful anticancer medicine directly into cells with Trop-2 proteins.
Information from laboratory studies suggest that this is how TRODELVY works. The clinical benefit of these observations is unknown.
Understanding what makes each treatment different can be confusing. This video will help break down the science to show you how TRODELVY is designed to work. Think of TRODELVY like a cargo ship designed to deliver anticancer medicine directly to cells with Trop-2 proteins. Watch to learn about TRODELVY from an oncologist and some unexpected guests.
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HOW TRODELVY IS DESIGNED TO WORK
TRODELVY®
Sacituzumab govitecan-hziy
180 mg for injection
WHAT IS TRODELVY?
TRODELVY® (sacituzumab govitecan-hziy) is a prescription medicine used to treat adults with:
It is not known if TRODELVY is safe and effective in people with moderate or severe liver problems or in children.
IMPORTANT SAFETY INFORMATION
TRODELVY can cause serious side effects, including low white blood cell count and diarrhea:
Do not receive TRODELVY if you have had a severe allergic reaction to TRODELVY. Ask your healthcare provider if you are not sure.
Please continue watching for Important Safety Information at the end of this video and please see link provided for Important Facts, including Important Warning.
The actors portrayed in this video are not actual TRODELVY patients. They are here for your education and entertainment. Enjoy.
Crystal:
I’m an info nerd. UFO sightings, beekeeping, or Barry Manilow’s greatest hits, you name it, I know it. So when I got my metastatic cancer diagnosis, I wanted to know everything I could about treatment options.
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TRODELVY®
Sacituzumab govitecan-hziy
180 mg for injection
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Right now, I’m looking at some firsthand experience with TRODELVY sacituzumab govitecan-hziy?
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Sacituzumab govitican hziy
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Is that a word? Has anyone here tried it?
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CRYSTAL
Curious about TRODELVY
Self-proclaimed Info Nerd
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TRODELVY? I haven’t tried that yet.
I’ll have to talk to my doctor about that one.
My doctor mentioned TRODELVY, but I haven’t looked into it.
I’ve been taking TRODELVY for three months now. What’s on your mind?
I’ve heard about TRODELVY but need to find more info too. Let me know what you learn.
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Amanda:
I’ve been taking TRODELVY for 3 months now. What’s on your mind?
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AMANDA
TRODELVY Patient and Champion
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Crystal:
I’ve probably got 100 questions, but how exactly does it work?
Amanda:
My doctor told me it delivers anticancer medicine into cells... But how it does that… I’m lousy at explaining things. Hold on one moment.
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My doctor told me it delivers anticancer medicine into cells…
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DR. ESPOSITO
Oncologist
(Has no idea she’s on mute)
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Amanda:
You’re on mute.
Dr. Esposito:
Sorry. Anyway, hey. I’m an oncologist. It is so good to see you again. Do more people want to learn about TRODELVY? That’s 4 just this week!
Crystal:
Wait, did you two plan this?
Dr. Esposito:
First, let’s look at cancer cells. They’re notoriously hard to destroy, smart, and may become resistant or may not respond at all to treatments.
TRODELVY takes a different approach when it comes to cancer cells.
Crystal:
Okay. I’m with you so far.
Dr. Esposito:
TRODELVY is known as an antibody-drug conjugate or ADC for short.
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Antibody-drug conjugate
ADC
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Amanda:
Uh, anti-what now?
Dr. Esposito:
Think of TRODELVY like a cargo ship. The TRODELVY ship is an antibody, and it’s carrying anticancer medicine.
Jim:
Woah, woah—not to knock the wind out of your sails, but I know a thing or two about ships. They need some type of navigation to see where they’re going. See, there was this one time I was lost at sea, and I had to navigate by sense of smell. We had nothing to eat but sea sponges and…
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JIM
TRODELVY patient
Lost at sea
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Dr. Esposito:
I can’t speak to the nutritional benefit of a sea sponge-based diet. Our SS TRODELVY is an antibody designed to seek out a specific protein called Trop-2. Compared with healthy cells, some cancer cells may have a higher amount of Trop-2.
Jim:
Trop-2... Do I need to see the first Trop to understand the sequel?
Amanda:
Good one. So these Trop-2 things enable TRODELVY to target cells?
Dr. Esposito:
The Trop-2 acts like a beacon, telling the TRODELVY ship to enter the docking area of that specific cell.
Jim:
What kind of cargo is this TRODELVY ship carrying anyway?
Dr. Esposito:
The cancer-fighting kind. Each TRODELVY ship can on average carry about 7 to 8 molecules of the anticancer medicine.
Crystal:
Holy ship!
Dr. Esposito:
Now, once TRODELVY docks in the cell, it delivers and releases the anticancer medicine, destroying the cell.
Crystal:
Wow! So TRODELVY is targeted at those cells with Trop-2? That sounds like a treatment option I’d like to try. I’ll discuss it with my doctor.
Dr. Esposito:
Information from laboratory studies suggest that this is how TRODELVY works. The clinical benefit of these observations is unknown.
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Information from laboratory studies suggest that this is how TRODELVY works. The clinical benefit of these observations is unknown.
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Crystal:
Thanks for talking me through how TRODELVY is designed to work. Is there any important safety information I should know about?
[Voiceover with text on-screen]:
I’m glad you asked. Here’s what you should know.
IMPORTANT SAFETY INFORMATION
TRODELVY can cause serious side effects, including low white blood cell count and diarrhea:
Do not receive TRODELVY if you have had a severe allergic reaction to TRODELVY. Ask your healthcare provider if you are not sure.
Allergic and infusion-related reactions which can be serious and life-threatening. Tell your healthcare provider or nurse right away if you get any of the following symptoms during your infusion of TRODELVY or within 24 hours after: swelling of your face, lips, tongue, or throat; hives; skin rash, itching, or flushing of your skin; fever; difficulty breathing or wheezing; lightheadedness, dizziness, feeling faint, or pass out; or chills or shaking chills (rigors).
Nausea and vomiting are common with TRODELVY and can sometimes be severe. Before each dose of TRODELVY, you will receive medicines to help prevent nausea and vomiting along with medicines to take home with instructions about how to take them. Call your healthcare provider right away if you have nausea or vomiting that is not controlled with the medicines prescribed for you. Your healthcare provider may decide to decrease your dose or stop TRODELVY if your nausea and vomiting is severe and cannot be controlled with anti-nausea medicines.
Before receiving TRODELVY, tell your healthcare provider about all of your medical conditions, including if you:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Certain medicines may affect the way TRODELVY works.
The most common side effects of TRODELVY include decreased white blood cell (leukocyte and lymphocyte) and red blood cell counts, feeling tired or weak, hair loss, constipation, increased sugar levels in the blood, decreased protein levels (albumin) in the blood, decreased appetite, changes in kidney function test, increased levels of enzyme called alkaline phosphatase in the blood (test for liver or bone problems), and decreased levels of magnesium, potassium, and sodium in the blood.
These are not all of the possible side effects of TRODELVY. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
WHAT IS TRODELVY?
TRODELVY (sacituzumab govitecan-hziy) is a prescription medicine used to treat adults with:
It is not known if TRODELVY is safe and effective in people with moderate or severe liver problems or in children.
Please see Important Facts, including Important Warning on TRODELVY.com.
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Crystal:
I just learned this for the first time, so I recommend you follow up with your doctor to see if TRODELVY is right for you.
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TRODELVY®
sacituzumab govitecan-hziy
180 mg for injection
GILEAD
This information does not constitute the provision of medical advice and should not substitute for clinical decision making.
TRODELVY, the TRODELVY logo, GILEAD, and the GILEAD logo are trademarks of Gilead Sciences, Inc., or its related companies. All other marks are the property of their respective owners.
© 2023 Gilead Sciences, Inc. All rights reserved. US-TROC-0123 02/23
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Scientists discovered that patients with certain types of cancer have tumor cells that often contain more Trop-2 protein than normal cells (or noncancer cells). TRODELVY binds to cells with Trop-2.
TRODELVY attaches
to Trop-2
Once attached, TRODELVY enters the cancer cell
Once TRODELVY enters, the anticancer medicine is released, killing the cell
TRODELVY® (sacituzumab govitecan-hziy) is a prescription medicine used to treat adults with triple-negative breast cancer (negative for estrogen and progesterone hormone receptors and HER2) that has spread to other parts of the body (metastatic) or cannot be removed by surgery, and who have received two or more prior treatments, including at least one treatment for metastatic disease.
It is not known if TRODELVY is safe and effective in people with moderate or severe liver problems or in children.
Do not receive TRODELVY if you have had a severe allergic reaction to TRODELVY. Ask your healthcare provider if you are not sure.
Allergic and infusion-related reactions which can be serious and life-threatening. Tell your healthcare provider or nurse right away if you get any of the following symptoms during your infusion of TRODELVY or within 24 hours after: swelling of your face, lips, tongue, or throat; hives; skin rash, itching, or flushing of your skin; fever; difficulty breathing or wheezing; lightheadedness, dizziness, feeling faint, or pass out; or chills or shaking chills (rigors).
Nausea and vomiting are common with TRODELVY and can sometimes be severe. Before each dose of TRODELVY, you will receive medicines to help prevent nausea and vomiting along with medicines to take home with instructions about how to take them. Call your healthcare provider right away if you have nausea or vomiting that is not controlled with the medicines prescribed for you. Your healthcare provider may decide to decrease your dose or stop TRODELVY if your nausea and vomiting is severe and cannot be controlled with anti-nausea medicines.
Before receiving TRODELVY, tell your healthcare provider about all of your medical conditions, including if you:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Certain medicines may affect the way TRODELVY works.
The most common side effects of TRODELVY include decreased white blood cell (leukocyte and lymphocyte) and red blood cell counts, feeling tired or weak, hair loss, constipation, increased sugar levels in the blood, decreased protein levels (albumin) in the blood, decreased appetite, changes in kidney function test, increased levels of enzyme called alkaline phosphatase in the blood (test for liver or bone problems), and decreased levels of magnesium, potassium, and sodium in the blood.
These are not all of the possible side effects of TRODELVY. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Please click to see Important Facts about TRODELVY, including Important Warning.